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G-CSF alone, G-CSF with cyclophosphamide or the mixture of G-CSF with a CXCR4 inhibitor may be thought of. Patients with Grade three or 4 TFR could also be treated for management of signs per the guidance for therapy of Grade 1 and 2 TFR.  Feel free to visit my web site:  http://www.visevi.it/index.php?option=com_k2&view=itemlist&task=user&id=1819615